Journal Article: Current safety issues with quadrivalent meningococcal conjugate vaccines

Reasoning:

• Patient received both the Menveo and Bexsero 10 days prior to coming into the ED
• Meningococcal vaccines are included in as part of routine vaccinations for people 11-18 years of age, and for those at increased risk of meningitis
• We wanted to determine whether this combination or other similar combinations of vaccines would lead to increased risk of developing Bell’s palsy

Purpose:

• To review the safety of quadrivalent meningococcal conjugate vaccines
• To identify potential areas for further research in terms of the safety of these vaccines

Methods:

• The authors performed a search through The Vaccine Adverse Event Reporting System (VAERS), which is co-administered by the FDA and CDC
• Data collected include demographics, vaccine type, date of receipt, adverse event experience, and medical history

Key Points:

• The most common side effects following Menveo injection are site erythema, swelling, warmth, pain, dizziness, syncope (but there are not unexpected findings)
• There is a statistically significant association of Bell’s palsy when Menveo was administered concomitantly with other vaccines (especially with HPV, Influenza, or Tdap), but this does not occur if Menveo is administered alone
  • Cohort study with 48,899 participants aged 11-21
• This presents a challenge since Menveo is often administered with other vaccines simply due to the vaccination schedule for adolescents

Conclusion:

• Further research needs to be conducted to better understand the relationship between Bell’s palsy and administering Menveo with other vaccines

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